9419 Norton Commons Blvd.
Suite 101, Prospect, KY 40059



Inspired by the recent discovery of the skin’s regeneration process, the scientists at DefenAge™ have identified how to unlock the key to youth with powerful peptides called Age-Repair Defensins™. Paradigm-shifting DefenAge is the FIRST and ONLY 4th generation skin care featuring this stand-alone breakthrough NATURAL mechanism of action. Patent-pending and exclusively available in DefenAge. We are pioneering the future of skin care!


Imagine if you could unlock your skin’s potential to stay youthful? Smooth, radiant and healthy looking skin is now at your fingertips with the introduction of breakthrough skin rejuvenating Age-Repair Defensins™!


Adult stem cells are found in many parts of the body such as the brain, bone marrow, fat, teeth, skin and hair follicles. Adult stem cells regenerate themselves naturally, under specific circumstances.

The DEFENAGE™ Difference


The skin is equipped with a primitive immune system. When a disruption occurs, a stem cell located in the hair follicle goes into a cycle of self-renewal, triggered by defensins, naturally occurring messenger peptides. Defensins trigger the production of an abundance of keratinocytes. These keratinocytes migrate to the top, to form the skin’s barrier, protecting the skin against external aggression, preventing moisture loss and ensuring optimal skin health.


The scientists at DefenAge have identified how to unlock the key to youth with powerful, synthetically produced messenger peptides called Age-Repair Defensins™. These patent-pending peptides are the FIRST of their kind and available EXCLUSIVELY in DefenAge skincare. Age-Repair Defensins™ are an age-correcting discovery, transported in a special liposome system. Combined with specially selected skincare ingredients to create an ideal bio-environment, skin rejuvenates its appearance NATURALLY and EFFECTIVELY

Visible correction of up to 16 signs of aging just in 6 weeks!

• Revives Youthful Firmness
• Brightens Age Spots
• Defines Contours
• Smoothes Lines
• Diminishes Wrinkles
• Unclogs & Minimizes Pores
• Comforts Sensitivity
• Evens Skin Tone
• Corrects Surface Imperfections
• Revives Clarity
• Replenishes Moisture
• Repairs Dryness
• Refines Texture
• Renews Softness
• Revitalizes Dullness
• Calms Redness

Frequently Asked Questions

Because your skin’s barrier is most likely damaged due to environmental exposure, stress, tobacco smoke, diet and ingredients in other skin care products, it may take up to 4 days to feel 24/7 Barrier Repair Cream’s deep moisture-repairing effects. This can be especially true if you are used to wearing rich, lubricious creams. These types of products artificially mask skin dryness rather than repair the damaged barrier that causes your skin to be dry, rough and uncomfortable. There is actually no need for these types of moisturizers when your skin’s barrier is normal and healthy-acting. 24/7 Barrier Repair Cream returns your skin to feeling and acting normal in less than a week. This lightweight cosmeceutical moisturizer contains ‘smart’ barrier repair ingredients and powerful surface antioxidants to seek out damaged areas of your skin’s barrier and repair them within 4 days. To experience this rapid repair yourself, please follow the directions for 24/7 Barrier Repair Cream by applying 3-4 pumps of cream over your face and neck twice daily after cleansing. Within 4 days your skin should feel more hydrated, more comfortable, smoother and less sensitive. Continued, regular applications will maintain your skin’s barrier and resistance to dryness caused by environmental factors.

Defensins are powerful regenerative peptides whose benefits were first linked to the immune system. They are also known for their antimicrobial effects. Recently, the age-repairing nature of these natural peptides was discovered by scientists at Progenitor Biologics™, the parent company of DefenAge Cosmeceuticals, while researching stem cell therapies for wound healing and Type I Diabetes. During the course of their research, scientists made an extraordinary discovery: two members of the defensin family have surprising benefits for aging skin in cosmeceutical skincare. Alpha-defensin 5 communicates specifically with skin’s Master Stem Cells to unlock the skin’s age-corrective potential. Beta-defensin 3 significantly improves skin’s barrier functions. This discovery was so novel and unexpected we are patenting the use of these peptides for anti-aging purposes.

Age-Repair Defensins is a proprietary blend of these powerful regenerative peptides combined with unique supporting molecules in a protective nanocapsule delivery system. The result is age-correcting activity that produces up to 18 years visible reduction in skin aging over 6 weeks of regular use*. DefenAge Cosmeceuticals is the first and only skincare to utilize these revolutionary peptides for their effects in visible age-correction.

When we say DefenAge™ products are ‘Free from animal- and human-derived ingredients’, we mean none of the ingredients in DefenAge™ Cosmeceuticals are sourced from vertebrate animals, including humans. This is important because certain types of disease and infections can be transferred from animals to humans and from humans to humans. Their refusal to use such sources eliminates these risks. Instead, they use the same alternative biosources used in the manufacture of drugs.

DefenAge™ does use one ingredient derived from an invertebrate. Sea whip is a Caribbean coral believed to be the strongest anti-inflammatory to come from the sea. Only the ‘skeletal’ portion of the sea whip is collected by harvesters, who leave the live animal unharmed and available to multiply. No known disease or infection source is transferrable from the coral to humans.

We know this is the reverse of other skin care lines so it probably seems unnatural to you. However, there is a very good reason why we ask you to do this. The cream contains ingredients that help the age-correcting ingredients in the serum to penetrate deeper into your skin’s surface. Putting the serum on first will limit this penetration so you will be less likely to see the dramatic improvements seen and felt by the participants in our clinical studies.

Both of these products contain dose-dependent ingredients to deliver their results. ‘Dose-dependent’ describes the specific amount of an ingredient required to produce visible results in the skin. This amount is usually identified in a clinical study where the product is applied twice a day. In order to ensure you see results, we suggest you apply the same amount of product with the same frequency used in the studies: twice a day.

Since the 24/7 Barrier Repair Cream contains a small amount of fragrance we do not recommend you apply it around your eyes. However, you can apply 8-in-1 BioSerum above and below your eyes.

While many cosmetic companies might describe DefenAge™ Cosmeceuticals as natural due to the large number of ingredients derived directly from nature, as scientists we do not. We define natural ingredients as having the same molecular structure as they had in nature, which many of our ingredients do. However, since we have reorganized some natural molecules to suit our formulation needs or created new molecules from natural sources we do not like to call our products ‘natural’.

Yes, if you want to.

Yes, our studies show a definite, noticeable brightening effect on the skin, including age spots, within the first week of use. Because skin brightening is the most sought-after skincare benefit, many companies offer skin lightening and brightening products. Most feature hydroquinone, a highly controversial ingredient banned in Europe and Japan due to questions about its safety. In addition to hydroquinone it is not unusual to see kojic acid, a skin sensitizer; bearberry (aka: uva ursi), which contains a natural form of hydroquinone; licorice PTH, an unstable natural skin brightener; or Vitamin C esters or salts, such as tetrahexyldecyl ascorbate or sodium ascorbyl phosphate. These ingredients can also be seen in combination without hydroquinone but do not offer the same degree of lightening within the same period as with hydroquinone, which is usually 2-3 months.

To our knowledge, none of these ingredients, either alone or in combination, totally relieves the appearance of age spots.

The DefenAge 24/7 Barrier Repair Cream and 8-in-1 BioSerum incorporate a revolutionary skin brightening technology, led by DefenAge’s™ patent-pending Age Repair Defensins™ to target skin discolorations at the source. When used in conjunction with the 2-Minute Reveal Masque twice weekly, residual unevenness and dead surface cells are lifted away. Within a week, the skin looks visibly brighter and skin discoloration is less apparent.

All products made by DefenAge™ Cosmeceuticals are tested on humans, not other animals. We do not believe animal studies are accurate enough to determine human safety. Nor are they ethical.

To prove safety DefenAge™ puts their products through a rigorous series of tests. Among these are:
• 30-Day HRIPT (Human Repeat Insult Patch Test) to determine irritancy and allergy potential of a leave-on product. Results are reviewed and signed by a board certified dermatologist.
• 14-Day Clinical Evaluation of Ophthalmologic Safety for all products used around the eye. Products are tested for safe use around the eye and for safe use by contact lens wearers.

Results are reviewed and signed by a board certified ophthalmologist.

Everything you need for dramatic age correction is included in 24/7 Barrier Repair Cream and 8-in-1 BioSerum, both applied twice a day; and 2-Minute Reveal Masque, applied 1-2 times a week. When used together as directed, within 6 weeks our clinical studies show significant improvement in up to 16 signs of aging:

1. Revives Youthful Firmness
2. Brightens Age Spots
3. Defines Contours
4. Smoothes Lines
5. Diminishes Wrinkles
6. Unclogs & Minimizes Pores
7. Comforts Sensitivity
8. Evens Skin Tone
9. Corrects Surface Imperfections
10. Revives Clarity
11. Replenishes Moisture
12. Repairs Dryness
13. Refines Texture
14. Renews Softness
15. Revitalizes Dullness
16. Calms Redness

Aging skin is a global condition that occurs in any skin type (dry, oily, normal, combination). Since all aging skin has the same basic needs, we’ve formulated each product for use by all skin types, thereby eliminating the need to analyze your skin. If your skin is aging, you can use our products.

DefenAge™ Cosmeceuticals is the only skincare with Age-Repair Defensins, a novel, non-prescription, patent-pending peptide complex known to communicate directly with skin’s Master Stem Cells. Clinical studies show visible age correction of up to 18 years in just 6 weeks. To our knowledge, DefenAge™ Cosmeceuticals is the only skincare clinically-proven to deliver these results. Based on results obtained from a six-week clinical study of participants aged 48-68 using 2-Minute Reveal Masque one-to-two times a week and 24/7 Barrier Repair Cream and 8-in-1 BioSerum twice daily. Results were measured using QuantifiCare™ Clinical Imaging System. Individual results may vary.

Schedule A Consultation

For more information about Defenage products, schedule a consultation with Dr. Samuels at 502-897-9411.

Our practice serves Louisville, KY and the surrounding areas.